The Mustaine family were Jehovah's Witnesses. His father was of French, German, Irish, and Finnish descent, while his mother was of German Jewish ancestry. Mustaine was born on September 13, 1961, in La Mesa, California, (a nearby suburb of San Diego) to parents Emily Marie ( née David) and John Jefferson Mustaine. In a popular vote on the internet forum of Ultimate Guitar, Mustaine was ranked third in the top 25 rhythm guitarists of all time, first in Joel McIver's book, The 100 Greatest Metal Guitarists, tenth in Loudwire's '66 Best Hard Rock + Metal Guitarists of All Time', and third in their '10 Greatest Rhythm Guitarists in Rock + Metal'.

Mustaine has been married to Pamela Anne Casselberry since 1991, with whom he has two children, Electra and Justis Mustaine. Mustaine has been to rehab throughout his life, fighting alcohol and drug problems, and briefly battled throat cancer in 2019. He now identifies as a born-again Christian. Mustaine was born into a family of Jehovah's Witnesses. He was, however, credited on four songs from Kill 'Em All and two songs from Ride the Lightning. Prior to forming Megadeth, Mustaine was the original lead guitarist of Metallica but did not appear on any albums. Mustaine has released sixteen studio albums with Megadeth, sold over 38 million records worldwide, with six albums platinum-certified, and won a Grammy Award for Best Metal Performance in 2017 at the 59th Grammy Awards, for the title track of their fifteenth studio album, Dystopia. He is the co-founder, frontman and primary songwriter of the thrash metal band Megadeth, as well as their sole consistent member. David Scott Mustaine (born September 13, 1961) is an American musician.

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